The ets gene family

Trends Biochem Sci. 1992 Jul;17(7):251-6. doi: 10.1016/0968-0004(92)90404-w.

Abstract

Ets proteins have a conserved DNA-binding domain and regulate transcriptional initiation from a variety of cellular and viral gene promoter and enhancer elements. Some members of the Ets family, Ets-1 and Ets-2, cooperate in transcription with the AP-1 transcription factor, the product of the proto-oncogene families, fos and jun, while others, Elk-1 and SAP-1, form ternary complexes with the serum response factor (SRF). Certain ets gene family members possess transforming activity while others are activated by proviral integration in erythroleukaemias.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • DNA-Binding Proteins / genetics
  • Enhancer Elements, Genetic
  • Gene Expression Regulation, Viral
  • Humans
  • Molecular Sequence Data
  • Protein-Tyrosine Kinases / genetics
  • Regulatory Sequences, Nucleic Acid / genetics
  • Retroviridae Proteins, Oncogenic / genetics*
  • Sequence Homology, Nucleic Acid
  • Transcriptional Activation / genetics

Substances

  • DNA-Binding Proteins
  • Retroviridae Proteins, Oncogenic
  • oncogene proteins v-ets
  • Protein-Tyrosine Kinases