Morphogenesis: shroom in to close the neural tube

Curr Biol. 2004 Feb 17;14(4):R150-1.

Abstract

A novel actin-binding protein, Shroom, localises to precisely those cells that will constrict during cranial neural tube closure and appears pivotal in regulating the apical constrictions that drive epithelial foldings in vertebrate embryos.

Publication types

  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Central Nervous System / embryology*
  • Central Nervous System / metabolism
  • Epithelium / embryology
  • Gene Expression Regulation*
  • Mice / embryology*
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*
  • Morphogenesis / genetics

Substances

  • Actins
  • Microfilament Proteins
  • Shrm protein, mouse