Par proteins: partners in polarization

Curr Biol. 2004 Feb 17;14(4):R160-2.

Abstract

Proteins can be localized either by inclusion or exclusion, and the Par polarity proteins illustrate both mechanisms. Cdc42 recruits Par-6 to a limited region of the plasma membrane. Par-6 recruits Par-3, which is actively removed from other regions by Par-1 and Par-5. Inclusion and exclusion together ensure efficient segregation of the polarity proteins.

Publication types

  • Review

MeSH terms

  • 14-3-3 Proteins
  • Animals
  • Caenorhabditis elegans Proteins / metabolism
  • Cell Polarity / genetics*
  • Models, Biological*
  • Phosphorylation
  • Protein Kinase C / metabolism
  • Protein-Serine-Threonine Kinases
  • Proteins / metabolism*
  • Signal Transduction*
  • Tyrosine 3-Monooxygenase / metabolism
  • cdc42 GTP-Binding Protein / metabolism*

Substances

  • 14-3-3 Proteins
  • Caenorhabditis elegans Proteins
  • Proteins
  • par-5 protein, C elegans
  • par-6 protein, C elegans
  • Tyrosine 3-Monooxygenase
  • PAR-3 protein, C elegans
  • Protein-Serine-Threonine Kinases
  • PKC-3 protein
  • Protein Kinase C
  • cdc42 GTP-Binding Protein