Abstract
We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Division / drug effects
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Cell Line, Tumor
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Humans
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Nitriles / chemical synthesis*
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Nitriles / chemistry
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Nitriles / pharmacology
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Protein-Tyrosine Kinases / antagonists & inhibitors*
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Quinolines / chemical synthesis*
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Quinolines / chemistry
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Quinolines / pharmacology
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Structure-Activity Relationship
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src-Family Kinases / antagonists & inhibitors*
Substances
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Antineoplastic Agents
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Nitriles
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Quinolines
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ARG tyrosine kinase
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Protein-Tyrosine Kinases
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src-Family Kinases