Plant RNAi: How a viral silencing suppressor inactivates siRNA

Phillip D Zamore

doi:10.1016/j.cub.2004.02.021

Plant RNAi: How a viral silencing suppressor inactivates siRNA

Curr Biol. 2004 Mar 9;14(5):R198-200. doi: 10.1016/j.cub.2004.02.021.

Author

Phillip D Zamore¹

Affiliation

¹ Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. pnillip.zamore@umassmed.edu

PMID: 15028237
DOI: 10.1016/j.cub.2004.02.021

Abstract

The three-dimensional structure of an siRNA bound to the tombusvirus p19 protein--a suppressor of gene silencing--provides a first glimpse into how plant viruses can defeat their host's anti-viral RNAi defenses.

Publication types

Review

MeSH terms

MicroRNAs / metabolism
Nucleic Acid Conformation
Plants / virology*
Protein Conformation
RNA Interference / physiology*
RNA, Small Interfering / metabolism*
RNA, Small Interfering / physiology
Tombusvirus / genetics*
Viral Proteins / genetics
Viral Proteins / metabolism*

Substances

MicroRNAs
RNA, Small Interfering
Viral Proteins