Day-hospital treatment of acute pericarditis: a management program for outpatient therapy

J Am Coll Cardiol. 2004 Mar 17;43(6):1042-6. doi: 10.1016/j.jacc.2003.09.055.


Objectives: We sought to investigate the safety and efficacy of a protocol for acute pericarditis triage and outpatient management of low-risk cases.

Background: Acute pericarditis has generally a brief and benign course after empiric treatment by non-steroidal anti-inflammatory drugs, and routine hospitalization of most patients may be unnecessary.

Methods: From January 1996 to December 2001, all consecutive cases of acute pericarditis were evaluated on a day-hospital basis. Patients without clinical poor prognostic predictors (fever >38 degrees C, subacute onset, immunodepression, trauma, oral anticoagulant therapy, myopericarditis, severe pericardial effusion, cardiac tamponade) were considered low-risk cases and assigned to outpatient treatment with high-dose oral aspirin. Patients with poor prognostic predictors or aspirin failure were hospitalized for etiology search and treatment. A clinical and echocardiographic follow-up was performed at 48 to 72 h, 7 to 10 days, 1 month, 6 months, and 1 year.

Results: Two hundred fifty-four out of 300 (84.7%) patients were selected as low-risk cases. Outpatient treatment was efficacious in 221 out of 254 (87%) cases. Thirty-three out of 254 patients were hospitalized because of aspirin failure. Patients treated on an out-of-hospital basis had no serious complications after a mean follow-up of 38 months (no cases of cardiac tamponade). A higher frequency of recurrences and constriction was recorded in aspirin-resistant cases than in aspirin responders (60.6% vs. 10.4% for recurrences and 9.1% vs. 0.5% for constriction, respectively; all p < 0.01).

Conclusions: A protocol for acute pericarditis triage and outpatient therapy of low-risk cases is safe and efficacious and may reduce management costs.

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aspirin / administration & dosage
  • Day Care, Medical / standards*
  • Day Care, Medical / statistics & numerical data
  • Decision Trees
  • Echocardiography
  • Female
  • Follow-Up Studies
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care*
  • Outpatient Clinics, Hospital / standards*
  • Outpatient Clinics, Hospital / statistics & numerical data
  • Pericarditis / diagnostic imaging
  • Pericarditis / economics
  • Pericarditis / pathology
  • Pericarditis / therapy*
  • Prospective Studies
  • Recurrence


  • Aspirin