BAG-1 in carcinogenesis

Expert Rev Mol Med. 2004 Mar 22;6(7):1-15. doi: 10.1017/S1462399404007537.


BAG-1 is a multifunctional protein that exists as several differentially localised and functionally distinct isoforms. BAG-1 isoforms interact with a diverse array of molecular targets and regulate a wide range of cellular processes, including proliferation, survival, transcription, apoptosis, metastasis and motility. The BAG domain of BAG-1 interacts with chaperone molecules and this is considered important for many BAG-1 functions. The ability of BAG-1 to regulate such a wide variety of cellular processes suggests it might play an important role in many cancer types. For example, regulation of nuclear hormone receptor function and susceptibility to apoptosis might have a major impact on cancer development, progression and response to therapy. There is also increasing evidence that BAG-1 expression is altered in a variety of human malignancies relative to normal cells, and with further understanding of BAG-1 function it might become a powerful prognostic/predictive marker in human cancer. This review describes the structure and function of BAG-1 isoforms and the potential clinical implications of their expression in tumour cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / metabolism
  • Cell Survival
  • Chaperonins / genetics
  • Chaperonins / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • HSC70 Heat-Shock Proteins / chemistry
  • HSC70 Heat-Shock Proteins / metabolism
  • Humans
  • Models, Molecular
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Neoplasms / physiopathology
  • Protein Binding
  • Protein Isoforms / chemistry
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism*
  • Protein Structure, Tertiary
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*


  • BCL2-associated athanogene 1 protein
  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • HSC70 Heat-Shock Proteins
  • Protein Isoforms
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • Chaperonins