A novel antioxidant-inhibited dexamethasone-mediated and caspase-3-independent muscle cell death

Ann N Y Acad Sci. 2003 Dec;1010:205-8. doi: 10.1196/annals.1299.035.

Abstract

Dexamethasone (Dex)-mediated cell death is associated with repression of survival factors (AP-1, c-myc, NF-kappaB). Dex suppressed the activity of genes encoding antioxidant enzymes leading to impaired viability and apoptotic cell death. These findings suggest that reactive oxygen species inhibit protein synthesis and amplify m-calpain-dependent proteolysis. The events that led to death of L6 muscle cells were most likely triggered by Dex-mediated repression of antioxidative defenses on the genomic level.

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Apoptosis / drug effects*
  • Caspase 3
  • Caspases / metabolism*
  • Cell Death / drug effects*
  • Cell Line
  • Cell Survival / drug effects
  • Dexamethasone / antagonists & inhibitors
  • Dexamethasone / pharmacology*
  • Muscle, Skeletal / cytology*
  • Muscle, Skeletal / drug effects

Substances

  • Antioxidants
  • Dexamethasone
  • Caspase 3
  • Caspases