PLAG proteins: how they influence apoptosis and cell proliferation

Ann N Y Acad Sci. 2003 Dec;1010:264-5. doi: 10.1196/annals.1299.045.

Abstract

Pleomorphic adenoma gene 1 product (PLAG1) a transcription factor with zinc finger domains, is upregulated in several tumors, such as pleomorphic adenomas and lipoblastomas. PLAGL2 is a second member of the same subfamily of zinc finger proteins. Cells overexpressing either of these two genes display the typical markers of neoplastic transformation. We investigated whether PLAG1 and PLAGL2 could prevent cells from undergoing apoptosis, leading them to grow uncontrollably.

MeSH terms

  • 3T3 Cells
  • Animals
  • Apoptosis / physiology*
  • Caspase 3
  • Caspase Inhibitors
  • Caspases / pharmacology
  • Cell Division / physiology*
  • Cysteine Proteinase Inhibitors / pharmacology
  • Mice
  • Proteins / physiology*

Substances

  • Caspase Inhibitors
  • Cysteine Proteinase Inhibitors
  • Proteins
  • Casp3 protein, mouse
  • Caspase 3
  • Caspases