The role of beta-glucuronidase in induction of apoptosis by genistein combined polysaccharide (GCP) in xenogeneic mice bearing human mammary cancer cells

Ann N Y Acad Sci. 2003 Dec:1010:347-9. doi: 10.1196/annals.1299.063.

Abstract

In order to reveal the mechanisms underlying genistein combined polysaccharide (GCP) inhibition of tumor proliferation, we investigated the effects of GCP on the growth of human breast cancer cells transplanted to athymic nude mice. We further investigated the metabolism of genistein and its association with the beta-glucuronidase activity in tumor and normal tissues.

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Apoptosis / physiology*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / pathology*
  • Cell Cycle / drug effects
  • Cell Division / drug effects
  • Female
  • Flow Cytometry
  • Genistein / pharmacology*
  • Glucuronidase / metabolism*
  • Humans
  • Mice
  • Polysaccharides / pharmacology*
  • Transplantation, Heterologous

Substances

  • Polysaccharides
  • genistein combined polysaccharide
  • Genistein
  • Glucuronidase