Dominant genes for colorectal cancer are not rare

Ann Hum Genet. 1992 May;56(2):99-103. doi: 10.1111/j.1469-1809.1992.tb01136.x.


The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0.006 with a lifetime penetrance of 0.63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Colorectal Neoplasms / genetics*
  • Female
  • Gene Frequency
  • Genes, Dominant*
  • Humans
  • Male
  • Middle Aged
  • Pedigree