Socializing with the neighbors: stem cells and their niche

Cell. 2004 Mar 19;116(6):769-78. doi: 10.1016/s0092-8674(04)00255-7.


The potential of stem cells in regenerative medicine relies upon removing them from their natural habitat, propagating them in culture, and placing them into a foreign tissue environment. To do so, it is essential to understand how stem cells interact with their microenvironment, the so-called stem cell niche, to establish and maintain their properties. In this review, we examine adult stem cell niches and their impact on stem cell biology.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / physiology
  • Cell Communication / physiology*
  • Cell Differentiation / physiology*
  • Cell Division / physiology
  • Cell Lineage / physiology*
  • Embryo, Mammalian / cytology
  • Embryo, Mammalian / embryology*
  • Embryo, Mammalian / metabolism
  • Embryo, Mammalian / ultrastructure
  • Humans
  • Organogenesis / physiology*
  • Signal Transduction / physiology
  • Stem Cells / metabolism*
  • Stem Cells / ultrastructure


  • Cell Adhesion Molecules