Abstract
The effects of two choline pivaloyl esters, [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium iodide (1) and [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium 2,2-dimethylpropionate (2), on learning and memory impairments induced in rats by scopolamine or lesions of nucleus basalis magnocellularis (NBM) have been evaluated by object recognition and Morris water maze tests in comparison with Tacrine (THA). Both 1 and 2 restored discrimination in object recognition test for assessing working-episodic memory and improved spatial memory in scopolamine or NBM-lesioned rats as well. The positive effects produced by 1 and 2 on cognitive and memory deficits were well comparable with those evoked by THA, used as reference compound.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetylcholinesterase / metabolism
-
Analysis of Variance
-
Animals
-
Basal Nucleus of Meynert / drug effects*
-
Basal Nucleus of Meynert / injuries
-
Basal Nucleus of Meynert / physiopathology
-
Cell Count
-
Choline / analogs & derivatives
-
Choline / pharmacology
-
Choline / therapeutic use
-
Cholinesterase Inhibitors / therapeutic use*
-
Cognition Disorders / chemically induced
-
Cognition Disorders / drug therapy*
-
Cognition Disorders / physiopathology
-
Discrimination Learning / drug effects
-
Dose-Response Relationship, Drug
-
Drug Interactions
-
Esters / therapeutic use
-
Immunohistochemistry / methods
-
Male
-
Maze Learning / drug effects
-
Memory Disorders / chemically induced
-
Memory Disorders / drug therapy*
-
Propiophenones / therapeutic use*
-
Quaternary Ammonium Compounds / therapeutic use*
-
Rats
-
Rats, Wistar
-
Scopolamine
-
Spatial Behavior / drug effects
-
Tacrine / pharmacology
-
Time Factors
Substances
-
(2-(2,2-dimethylpropionyloxy)ethyl)trimethylammonium
-
Cholinesterase Inhibitors
-
Esters
-
Propiophenones
-
Quaternary Ammonium Compounds
-
metamfepramone
-
phenyltrimethylammonium
-
Tacrine
-
Scopolamine
-
Acetylcholinesterase
-
Choline