Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development

Mech Ageing Dev. 2004 Feb;125(2):113-5. doi: 10.1016/j.mad.2003.11.005.


New blood vessel formation is important in many physiological process, including development, wound repair, and tumor growth. In aged animals, angiogenesis is reduced resulting in poor wound healing. We have identified a novel small molecule, thymosin beta(4), that promotes angiogenesis and wound repair in both normal and aged rodents. It also promotes hair growth in normal and aged rodents. It acts by increasing angiogenesis and cell migration and is currently in clinical trials for wound repair.

MeSH terms

  • Aging / physiology
  • Animals
  • Epidermis / injuries*
  • Epidermis / physiology
  • Hair Follicle / drug effects*
  • Hair Follicle / physiology
  • Mice
  • Neovascularization, Physiologic / drug effects*
  • Thymosin / pharmacology*
  • Wound Healing / drug effects*


  • thymosin beta(4)
  • Thymosin