Strategies for dealing with metabolite elucidation in drug discovery and development

Drug Discov Today. 2004 Apr 1;9(7):317-27. doi: 10.1016/S1359-6446(03)03018-6.


Structural information on metabolites can be a considerable asset for enhancing and streamlining the process of developing new drug candidates. Modern approaches that generate and use metabolite structural information can accelerate the drug discovery and development process by eliminating potentially harmful candidates earlier in the process and improving the safety of new drugs. This review examines the relative merits of current and potential strategies for dealing with metabolite characterization.

Publication types

  • Review

MeSH terms

  • Animals
  • Biotransformation
  • Clinical Trials as Topic
  • Drug Design*
  • Drug Evaluation, Preclinical
  • Humans
  • Pharmaceutical Preparations / chemistry
  • Pharmaceutical Preparations / metabolism*
  • Pharmacology, Clinical*


  • Pharmaceutical Preparations