Relating Biochemistry and Function in the Myosin Superfamily

Curr Opin Cell Biol. 2004 Feb;16(1):61-7. doi: 10.1016/j.ceb.2003.11.011.

Abstract

All characterized myosins share a common ATPase mechanism. However, detailed kinetic analyses suggest that modulation of the rate and equilibrium constants that define the ATPase cycle confers specific properties to these motor proteins, suiting them to specific physiological tasks. Understanding the kinetic mechanisms allows potential cellular functions of the different myosin classes and isoforms to be better defined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Isoenzymes / chemistry
  • Isoenzymes / classification
  • Isoenzymes / metabolism
  • Kinetics
  • Myosin Heavy Chains / physiology
  • Myosins / chemistry
  • Myosins / classification
  • Myosins / metabolism*

Substances

  • Isoenzymes
  • myosin VI
  • Myosin Heavy Chains
  • Myosins