Abstract
Emerin is an integral protein of the nuclear inner membrane. Emerin is not essential, but its loss of function causes Emery-Dreifuss muscular dystrophy. We summarize significant recent progress in understanding emerin, which was previously known to interact with barrier-to-autointegration factor and lamins. New partners include transcription repressors, an mRNA splicing regulator, a nuclear membrane protein named nesprin, nuclear myosin I and F-actin. These interactors imply multiple roles for emerin in the nucleus, some of which overlap with related LEM-domain proteins.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Gene Expression Regulation
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Humans
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Lamins / metabolism
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Membrane Proteins / physiology*
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Muscular Dystrophy, Emery-Dreifuss / etiology
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Mutation
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Nuclear Proteins / physiology*
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Thymopoietins / genetics
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Thymopoietins / metabolism
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Thymopoietins / physiology*
Substances
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BANF1 protein, human
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DNA-Binding Proteins
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Lamins
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Membrane Proteins
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Nuclear Proteins
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Thymopoietins
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emerin