Terminology and classification of the cortical dysplasias

Neurology. 2004 Mar 23;62(6 Suppl 3):S2-8. doi: 10.1212/01.wnl.0000114507.30388.7e.


Background: There have been difficulties in achieving a uniform terminology in the literature regarding issues of classification with respect to focal cortical dysplasias (FCDs) associated with epilepsy.

Objective: S: To review and refine the current terminology and classification issues of potential clinical relevance to epileptologists, neuroradiologists, and neuropathologists dealing with FCD.

Methods: A panel discussion of epileptologists, neuropathologists, and neuroradiologists with special expertise in FCD was held.

Results: The panel proposed 1) a specific terminology for the different types of abnormal cells encountered in the cerebral cortex of patients with FCD; 2) a reappraisal of the different histopathologic abnormalities usually subsumed under the term "microdysgenesis," and suggested that this terminology be abandoned; and 3) a more detailed yet straightforward classification of the various histopathologic features that usually are included under the heterogeneous term of "focal cortical dysplasia."

Conclusion: The panel hopes that these proposals will stimulate the debate toward more specific clinical, imaging, histopathologic, and prognostic correlations in patients with FCD associated with epilepsy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Brain Diseases / classification*
  • Brain Diseases / complications
  • Brain Diseases / pathology
  • Cerebral Cortex / abnormalities*
  • Cerebral Cortex / pathology*
  • Epilepsy / complications
  • Humans
  • Nervous System Malformations / classification*
  • Nervous System Malformations / complications
  • Nervous System Malformations / pathology
  • Neurons / pathology
  • Terminology as Topic*