Cognitive side effects of antiepileptic drugs in children

Neurology. 2004 Mar 23;62(6):872-7. doi: 10.1212/01.wnl.0000115653.82763.07.

Abstract

Cognitive impairment associated with antiepileptic drug (AED) therapy in children is an important concern given the potential negative effects of treatment on school learning and performance. Unfortunately, there have been few studies examining the cognitive effects of AEDs in this population and no adequate studies of newer AEDs. This article will discuss the effects of the traditional and newer AEDs on neuropsychological function in children. Because of various limitations in the designs of these studies, however, many of the studies report inconclusive findings. Although it will be necessary to overcome many programmatic and procedural hurdles, well-designed randomized prospective studies that are of adequate length to determine how AEDs ultimately relate to school performance and social adjustment are needed to firmly establish the cognitive and behavioral effects of AEDs in children.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Animals
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Behavior / drug effects
  • Child
  • Child, Preschool
  • Cognition Disorders / chemically induced*
  • Cognition Disorders / diagnosis*
  • Epilepsy / drug therapy*
  • Humans
  • Infant
  • Intelligence Tests / statistics & numerical data
  • Learning Disabilities / chemically induced
  • Learning Disabilities / diagnosis
  • Longitudinal Studies
  • Risk Assessment

Substances

  • Anticonvulsants