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. 2004 Mar;62(3):483-8.

[Eradication Effect of Lansoprazole-Based Triple Therapy Against H. Pylori]

[Article in Japanese]
  • PMID: 15038091

[Eradication Effect of Lansoprazole-Based Triple Therapy Against H. Pylori]

[Article in Japanese]
Toshiro Sugiyama et al. Nihon Rinsho. .


Eradication of H. pylori provides a potential cure in the majority of patients with gastric ulcer as well as duodenal ulcer. Two proton pump inhibitor(PPI)-based triple therapy, combining with clarithromycin(CAM), amoxicillin(AMPC) or metronidazole have been established as standard regimens worldwide. In Japan, lansoprazole(LPZ)-based triple therapy combined with CAM and AMPC for 1 week was firstly investigated on eradication effect against H. pylori and determination of the optimal dose of CAM in multicenter, double-blind trial. Patients with active gastric ulcer or duodenal ulcer were enrolled in this study. The eradication rate of H. pylori in patients with gastric ulcer were 0%, 87.5% and 89.2% and those in patients with duodenal ulcer were 4.4%, 91.1% and 83.7% in LPZ(60 mg/d) alone, LPZ(60 mg/d) with CAM(400 mg/d) and AMPC(1,500 mg/d), LPZ(60 mg/d) with CAM(800 mg/d) and AMPC(1,500 mg/d), respectively, in the full set analysis. LPZ-based triple therapy demonstrated a high eradication rate and was safe. In addition, the combination regimens with lower or higher dose of CAM were equivalent in Japanese patients.

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    Leontiadis GI, Moayyedi P, Ford AC. Leontiadis GI, et al. BMJ Clin Evid. 2009 Oct 1;2009:0406. BMJ Clin Evid. 2009. PMID: 21718575 Free PMC article. Review.

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