Iron-catalyzed cross-coupling of primary and secondary alkyl halides with aryl grignard reagents

Masaharu Nakamura; Keiko Matsuo; Shingo Ito; Eiichi Nakamura

doi:10.1021/ja049744t

Iron-catalyzed cross-coupling of primary and secondary alkyl halides with aryl grignard reagents

J Am Chem Soc. 2004 Mar 31;126(12):3686-7. doi: 10.1021/ja049744t.

Authors

Masaharu Nakamura¹, Keiko Matsuo, Shingo Ito, Eiichi Nakamura

Affiliation

¹ Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. masaharu@chem.s.u-tokyo.ac.jp

PMID: 15038701
DOI: 10.1021/ja049744t

Abstract

An iron-catalyzed cross-coupling reaction of a primary or secondary alkyl halide with an aryl Grignard reagent proceeds under mild conditions to give the corresponding coupling product in quantitative yield.