[Effects of 7-oxo-DHEA treatment on the immunoreactivity of BALB/c mice subjected to chronic mild stress]

Yao Xue Xue Bao. 2003 Dec;38(12):881-4.
[Article in Chinese]


Aim: To determine whether 7-oxo-dehydroepiandrosterone (7-oxo-DHEA) can reverse the hypoimmunity in BALB/c mice exposed to chronic mild stress.

Methods: A chronic mild stress animal model was established by subjecting BALB/c mice to a stressful regimen arranged in an unpredicted manner for 4 consecutive weeks. Immunological function alternations under chronic mild stress were assessed by lymphocytes proliferative response to mitogens and NK cell lysis activity test.

Results: The studies showed the correlation between the state of depression and abnormalities in the immune response, such as a decrease of T lymphocytes proliferative response to Con A and suppression of cytotoxic of NK cell. Meanwhile, significant decrease of T3 and T4 levels was also observed. When stressed mice were daily given 7-oxo-DHEA 15 mg.kg-1, lymphocyte proliferative response and the NK cell activity were significantly enhanced and the decreased levels of T3 and T4 were restored in the stressed mice.

Conclusion: 7-oxo-DHEA can improve the depressive symptoms and hypoimmunity of BALB/c mice induced by chronic mild stress as its parent DHEA.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / pharmacology
  • Animals
  • Antidepressive Agents / pharmacology
  • Cell Division / drug effects
  • Chronic Disease
  • Dehydroepiandrosterone / analogs & derivatives*
  • Dehydroepiandrosterone / pharmacology*
  • Killer Cells, Natural / immunology
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Stress, Physiological / blood
  • Stress, Physiological / immunology*
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / pathology
  • Thyroxine / blood
  • Triiodothyronine / blood


  • Adjuvants, Immunologic
  • Antidepressive Agents
  • Triiodothyronine
  • 7-oxodehydroepiandrosterone
  • Dehydroepiandrosterone
  • Thyroxine