Endocytic Recycling

Nat Rev Mol Cell Biol. 2004 Feb;5(2):121-32. doi: 10.1038/nrm1315.

Abstract

After endocytosis, most membrane proteins and lipids return to the cell surface, but some membrane components are delivered to late endosomes or the Golgi. We now understand that the pathways taken by internalized molecules that eventually recycle to the cell surface can be surprisingly complex and can involve a series of sorting events that occur in several organelles. The molecular basis for many of these sorting processes is only partly understood.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Cell Membrane / metabolism*
  • Clathrin-Coated Vesicles / metabolism
  • Endocytosis*
  • Endosomes / metabolism
  • Lipid Metabolism
  • Organelles / metabolism
  • Protein Transport
  • rab GTP-Binding Proteins / metabolism

Substances

  • rab GTP-Binding Proteins