Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP

Mol Biol Rep. 2004 Mar;31(1):59-63. doi: 10.1023/b:mole.0000013504.88003.32.


Supernatant protein factor (SPF) and alpha-tocopherol-associated protein (TAP) both belong to a widespread lipid-binding Sec 14-like protein family. All the members of the family have the lipid-binding motif called CRAL_TRIO. SPF is showed to stimulate the conversion of squalene to lanosterol and enhance cholesterol biosynthesis. TAP is identified to be involved in the intracellular distribution of alpha-tocopherol. Recently TAP is identified as SPF though they have very different functions. Here we report a human SPF/TAP homology SEC14L3 with 2082 base pairs in length and contains an open reading frame encoding a 400 amino acids protein. Analysis shows that SEC14L3 is mapped to 22q12 and expresses only in the liver among the used sixteen tissues in the test.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters
  • Amino Acid Sequence
  • Binding Sites
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism*
  • Chromosomes, Human, Pair 22
  • DNA, Complementary / genetics
  • Gene Expression Regulation*
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • Lipid Metabolism
  • Lipoproteins / metabolism*
  • Liver / physiology
  • Molecular Sequence Data
  • Proteins / genetics*
  • Proteins / metabolism*
  • Sequence Analysis
  • Sequence Homology, Amino Acid
  • Trans-Activators / metabolism*


  • ATP-Binding Cassette Transporters
  • Carrier Proteins
  • DNA, Complementary
  • Histocompatibility Antigens Class I
  • Lipoproteins
  • Proteins
  • SEC14L2 protein, human
  • SEC14L3 protein, human
  • Trans-Activators
  • transporter associated with antigen processing (TAP)

Associated data

  • GENBANK/AY240872