Human antibody-Fc receptor interactions illuminated by crystal structures

Nat Rev Immunol. 2004 Feb;4(2):89-99. doi: 10.1038/nri1266.


Immunoglobulins couple the recognition of invading pathogens with the triggering of potent effector mechanisms for pathogen elimination. Different immunoglobulin classes trigger different effector mechanisms through interaction of immunoglobulin Fc regions with specific Fc receptors (FcRs) on immune cells. Here, we review the structural information that is emerging on three human immunoglobulin classes and their FcRs. New insights are provided, including an understanding of the antibody conformational adjustments that are required to bring effector cell and target cell membranes sufficiently close for efficient killing and signal transduction to occur. The results might also open up new possibilities for the design of therapeutic antibodies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antibodies / chemistry*
  • Antibodies / immunology*
  • Crystallography, X-Ray
  • Humans
  • Models, Molecular
  • Protein Binding
  • Protein Structure, Tertiary
  • Receptors, Fc / chemistry*
  • Receptors, Fc / immunology*
  • Signal Transduction


  • Antibodies
  • Receptors, Fc