Role of the cytoskeleton during leukocyte responses

Nat Rev Immunol. 2004 Feb;4(2):110-22. doi: 10.1038/nri1268.


The cytoskeleton is a cellular network of structural, adaptor and signalling molecules that regulates most cellular functions that are related to the immune response, including migration, extravasation, antien recognition, activation and phagocytosis by different subsets of leukocytes. Recently, a large number of regulatory elements and structural constituents of the leukocyte cytoskeleton have been identified. In this review, we discuss the composition and regulation of the different cytoskeletal elements and their role in immune responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / immunology
  • Animals
  • Apoptosis / immunology
  • Cell Movement / immunology
  • Cytoskeleton / immunology*
  • Humans
  • Leukocytes / immunology*
  • rho GTP-Binding Proteins / immunology


  • rho GTP-Binding Proteins