Evaluation of aortic stiffness in tobacco-smoking adolescents

J Adolesc Health. 2004 Apr;34(4):339-43. doi: 10.1016/j.jadohealth.2003.07.012.


Purpose: To measure the aortic stiffness in tobacco-smoking adolescents and to investigate its relationship to tobacco smoke.

Methods: Aortic strain (S), pressure strain elastic modulus (E(p)), and normalized E(p) (E(p)*) in tobacco-smoking adolescents and the healthy control group were measured by a sphygmomanometer with cuff and transthoracic echocardiography. The study group consisted of 30 healthy cases (M/F: 27/3) as a control group and 30 tobacco-smoking volunteer adolescents (M/F: 28/2). Unpaired Student's t-test was used for comparison of these groups.

Results: The mean ages were 16.1 +/- 1.8 years and 16.2 +/- 1.4 years, respectively. The number of cigarettes smoked per day was 31 +/- 7.1 and the duration of smoking was 3.4 +/- 1.1 years. S, E(p) and E(p)* measurements of tobacco smokers were different than the control groups' and this difference was statistically significant. S values were significantly higher in nonsmokers than in smokers; whereas E(p) and E(p)* values were significantly higher in smoker group.

Conclusions: This study demonstrated that measurement of aortic stiffness with S, E(p), and E(p)* can be used as an early indicator of atherosclerosis in tobacco-smoking adolescents.

MeSH terms

  • Adolescent
  • Aortic Diseases / diagnosis
  • Aortic Diseases / epidemiology
  • Aortic Diseases / etiology*
  • Arteriosclerosis / etiology
  • Blood Pressure
  • Case-Control Studies
  • Echocardiography
  • Female
  • Humans
  • Male
  • Smoking / adverse effects*
  • Smoking / epidemiology
  • Turkey / epidemiology