Atrial fibrillation following chemotherapy for stage IIIE diffuse large B-cell gastric lymphoma in a patient with myotonic dystrophy (Steinert's disease)

Ann Hematol. 2005 Mar;84(3):192-3. doi: 10.1007/s00277-004-0867-6. Epub 2004 Mar 23.


The authors describe the unusual association between diffuse B-cell gastric lymphoma and myotonic dystrophy, the most common form of adult muscular dystrophy, and sudden atrial fibrillation following one cycle of doxorubicin-based chemotherapy in the same patient. Atrial fibrillation or other cardiac arrhythmias are unusual complications in patients treated with chemotherapy. The cardiac toxicity intrinsically associated with the aggressive chemotherapy employed could function as a triggering factor for the arrhythmia in the predisposed myocardium of this patient.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Atrial Fibrillation / chemically induced*
  • Doxorubicin / adverse effects
  • Humans
  • Lymphoma, B-Cell / complications
  • Lymphoma, B-Cell / drug therapy
  • Lymphoma, B-Cell / pathology
  • Lymphoma, Large B-Cell, Diffuse / complications*
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Male
  • Middle Aged
  • Myotonic Dystrophy / complications*
  • Neoplasm Staging
  • Stomach Neoplasms / complications*
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / pathology


  • Antineoplastic Agents
  • Doxorubicin