Physiological functions of protein kinase B/Akt

Biochem Soc Trans. 2004 Apr;32(Pt 2):350-4. doi: 10.1042/bst0320350.

Abstract

The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments. During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated. In this paper, we focus on the phenotypes of these PKB/Akt overexpression and mutant mice that may help to elucidate the functions exerted by PKB/Akt in mammals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / pathology
  • Diabetes Mellitus / pathology
  • Disease Models, Animal
  • Female
  • Humans
  • Lymphoma / pathology
  • Male
  • Mammary Glands, Animal / metabolism
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Milk / metabolism
  • Mutation
  • Myocardium / metabolism
  • Phenotype
  • Prostatic Neoplasms / metabolism
  • Protein-Serine-Threonine Kinases / genetics*
  • Protein-Serine-Threonine Kinases / physiology*
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-akt
  • Thymus Neoplasms / pathology

Substances

  • Proto-Oncogene Proteins
  • AKT1 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt