Abstract
Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Chlamydia Infections / drug therapy*
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Chlamydia Infections / microbiology*
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Chlamydophila pneumoniae / drug effects*
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Chlamydophila pneumoniae / growth & development
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Chlamydophila pneumoniae / ultrastructure
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Fluorescent Antibody Technique
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HeLa Cells
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Humans
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Microscopy, Electron