Macrolide resistance determinants of invasive and noninvasive group B streptococci in a Turkish hospital

Antimicrob Agents Chemother. 2004 Apr;48(4):1410-2. doi: 10.1128/AAC.48.4.1410-1412.2004.

Abstract

Macrolide resistance in 156 consecutive group B streptococcal isolates was investigated. Thirty-five isolates (22.4%) had inducible (80%) or constitutive (20%) erythromycin resistance. The genes responsible were erm(B), erm(A) subclass erm(TR), and erm(B) plus erm(TR) in 62.9, 2.9, and 8.6% of isolates, respectively. Nine isolates (25.7%) harbored neither mef nor detectable erm genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Clindamycin / pharmacology
  • Drug Resistance, Bacterial / genetics
  • Erythromycin / pharmacology
  • Female
  • Genes, Bacterial / genetics
  • Genes, Bacterial / physiology
  • Humans
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests
  • Rectum / microbiology
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / microbiology
  • Streptococcus agalactiae / drug effects*
  • Streptococcus agalactiae / genetics*
  • Turkey / epidemiology
  • Vagina / microbiology

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • Clindamycin
  • Erythromycin