2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread

Antimicrob Agents Chemother. 2004 Apr;48(4):1422-5. doi: 10.1128/AAC.48.4.1422-1425.2004.

Abstract

Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology*
  • Borna Disease / virology
  • Borna disease virus / drug effects*
  • Chlorocebus aethiops
  • Cytarabine / pharmacology
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / pharmacology*
  • RNA, Viral / biosynthesis
  • RNA, Viral / genetics
  • Vero Cells
  • Virus Replication / drug effects*

Substances

  • Antiviral Agents
  • RNA, Viral
  • Cytarabine
  • Deoxycytidine
  • 2'-fluoro-2'-deoxycytidine