[Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause]

Vopr Pitan. 2004;73(1):19-23.
[Article in Russian]

Abstract

Blind randomized placebo-control research included 39 women. The following criteria were: menopause period for more then 1 year long; diabetes mellitus; arterial hypertension; hypercholesterolemia. The patients were divided into two groups. Women from the first group (N = 24) were given 30 mg lycopene (composed with "Tomatol") per day during 24 weeks. The second group (N = 15) were given placebo. It was showed that during 12-week "Tomatol" intake we state that lycopene concentration in serum increased twice (337.0 +/- 133.0 nM), total cholesterol (CH) and CH LDL decreased by 12% and 16% respectively. The lipoproteins spectrum normalization correlated to serum antioxidative activity (r = 0.30, p < 0.05), and malonic dialdehyde concentration decrease by 44.8% correlated to lycopene increase (r = -0.51, p < 0.05). Our results give us a possibility to use "Tomatol" as an additional medicine for the prevention of atherosclerosis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Arteriosclerosis / etiology
  • Arteriosclerosis / prevention & control*
  • Carotenoids / administration & dosage
  • Carotenoids / therapeutic use*
  • Cholesterol / blood
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / complications
  • Double-Blind Method
  • Female
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / complications
  • Hypertension / blood
  • Hypertension / complications
  • Hypolipidemic Agents / administration & dosage
  • Hypolipidemic Agents / therapeutic use*
  • Lipoproteins / blood*
  • Lipoproteins, LDL / blood
  • Lycopene
  • Postmenopause / blood*
  • Treatment Outcome

Substances

  • Hypolipidemic Agents
  • Lipoproteins
  • Lipoproteins, LDL
  • Carotenoids
  • Cholesterol
  • Lycopene