Allele-specific gene expression uncovered

Trends Genet. 2004 Mar;20(3):113-6. doi: 10.1016/j.tig.2004.01.001.


Genetic variation in populations can result in variation in levels of gene expression but the extent to which this occurs has been unclear. In this article, recent studies of allele-specific expression among autosomal non-imprinted genes are reviewed. These new data provide evidence that differential expression is relatively common and that allelic differences are heritable and can be highly context specific.

Publication types

  • Review

MeSH terms

  • Alleles*
  • Gene Expression Regulation / genetics*
  • Genetic Variation / genetics
  • Genome, Human*
  • Genomic Imprinting / genetics
  • Humans