Immune Responses to Puumala Virus Infection and the Pathogenesis of Nephropathia Epidemica

Microbes Infect. 2004 Feb;6(2):238-45. doi: 10.1016/j.micinf.2003.10.017.

Abstract

Puumala virus, causative agent of a mild form of hemorrhagic fever with renal syndrome, also known as nephropathia epidemica, induces long-lasting humoral and cellular immunity in patients. The virus itself is not cytopathic, and the immune responses to the virus may be involved in teh pathogenesis of the disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Hantavirus Infections / epidemiology
  • Hantavirus Infections / immunology
  • Hemorrhagic Fever with Renal Syndrome / immunology*
  • Hemorrhagic Fever with Renal Syndrome / pathology
  • Hemorrhagic Fever with Renal Syndrome / physiopathology
  • Hemorrhagic Fever with Renal Syndrome / virology
  • Humans
  • Puumala virus*