The choice of proton pump inhibitor: does it matter?

Basic Clin Pharmacol Toxicol. 2004 Mar;94(3):106-11. doi: 10.1111/j.1742-7843.2004.pto940302.x.


Proton pump inhibitors are used at different dosages for the treatment of acid-related gastrointestinal disorders, such as gastro-oesophaeal reflux and peptic ulcer disease. Comparisons of four different proton pump inhibitors: lansoprazole, omeprazole, pantoprazole, and rabeprazole show that they all have similar potency and efficacy. Rabeprazole, however, displays a slightly more rapid onset of acid inhibition than the others; the clinical advantage of this seems limited. The S-isomer of omeprazole, esomeprazole, exhibits a somewhat higher potency than the other proton pump inhibitors. Reports supporting a clinical advantage of this property are not convincing. To conclude, all inhibitors seem comparable as regards inhibition of gastric acid secretion.

Publication types

  • Review

MeSH terms

  • Anti-Ulcer Agents / therapeutic use*
  • Esophagitis, Peptic / drug therapy
  • Gastric Acid / metabolism
  • Humans
  • Peptic Ulcer / drug therapy
  • Proton Pump Inhibitors*


  • Anti-Ulcer Agents
  • Proton Pump Inhibitors