This article reports data on epidemiological survey carried out in a population of Sardinia. The aim of the research was to evaluate lifestyles and sociodemographic factors related and their changes in time by health promotion interventions. The authors analyzed smoking habit by gender, age and educational level with Multivariate analysis by Logistic Regression. The results show in males aged 20-64 years the prevalence of current smokers decreases in value with the increasing of educational level, while in males >64 years educational level has not an influence. In females 20-39 years the prevalence of smokers decreases with the increasing of educational level, while >40 years this prevalence increased with high educational level. Younger male smokers are decreasing in higher social categories, while younger female smokers are now increasing in lower social class. These results emphasize on necessities of reassessment in health promotion priorities.