Elevated blood histamine caused by vaccinations and Vitamin C deficiency may mimic the shaken baby syndrome

Med Hypotheses. 2004;62(4):533-6. doi: 10.1016/j.mehy.2003.12.023.


The findings of subdural hematoma and retinal hemorrhages in infants, without any documented history of major trauma, do not always indicate child abuse. A combination of ascorbate depletion and the injection of foreign proteins can cause a very high blood histamine level, leading to capillary fragility and venular bleeding. This can be prevented by the administration of vitamin C.

MeSH terms

  • Ascorbic Acid / administration & dosage
  • Ascorbic Acid / blood
  • Ascorbic Acid Deficiency / blood*
  • Ascorbic Acid Deficiency / diet therapy
  • Ascorbic Acid Deficiency / pathology
  • Capillary Fragility
  • Hematoma, Subdural / etiology
  • Histamine / blood*
  • Humans
  • Infant, Newborn
  • Retinal Hemorrhage / etiology
  • Shaken Baby Syndrome / prevention & control*
  • Vaccination / adverse effects*


  • Histamine
  • Ascorbic Acid