Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

Cell. 1992 Aug 21;70(4):609-20. doi: 10.1016/0092-8674(92)90430-k.

Abstract

Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / isolation & purification
  • Drosophila / embryology
  • Drosophila / genetics*
  • Drosophila Proteins*
  • Eye Proteins / genetics*
  • Eye Proteins / isolation & purification
  • Gene Expression Regulation
  • Molecular Sequence Data
  • Morphogenesis
  • Mutation
  • Photoreceptor Cells / embryology*
  • Repressor Proteins*
  • Sequence Alignment
  • Transcription Factors / genetics*

Substances

  • AOP protein, Drosophila
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Eye Proteins
  • Repressor Proteins
  • Transcription Factors

Associated data

  • GENBANK/L05499
  • GENBANK/M87278
  • GENBANK/M94264
  • GENBANK/M97693
  • GENBANK/M97694
  • GENBANK/S72766
  • GENBANK/S72767
  • GENBANK/S72768
  • GENBANK/S72769
  • GENBANK/S72771