The New Kid on the Block(ade) of the IGF-1 Receptor

Cancer Cell. 2004 Mar;5(3):201-2. doi: 10.1016/s1535-6108(04)00054-6.

Abstract

The insulin-like growth factors (IGF) system, and particularly the IGF-1 receptor, has recently become the subject of major interest in the arena of cancer research. Its involvement in cancer cell growth and survival makes the system an excellent target as potential adjunct therapy to standard chemotherapy.

Publication types

  • Review

MeSH terms

  • Cell Division / physiology
  • Cell Survival / physiology
  • Enzyme Inhibitors / pharmacology
  • Insulin-Like Growth Factor I / antagonists & inhibitors
  • Insulin-Like Growth Factor I / metabolism*
  • Ligands
  • Protein Binding
  • Protein Structure, Tertiary
  • Receptor, IGF Type 1 / drug effects
  • Receptor, IGF Type 1 / metabolism*
  • Signal Transduction / physiology

Substances

  • Enzyme Inhibitors
  • Ligands
  • Insulin-Like Growth Factor I
  • Receptor, IGF Type 1