Biscoumarin: new class of urease inhibitors; economical synthesis and activity

Khalid Mohammed Khan; Sajid Iqbal; Muhammad Arif Lodhi; Ghulam Murtaza Maharvi; Zia Ullah; Muhammad Iqbal Choudhary; Atta-Ur Rahman; Shahnaz Perveen

doi:10.1016/j.bmc.2004.01.010

Biscoumarin: new class of urease inhibitors; economical synthesis and activity

Bioorg Med Chem. 2004 Apr 15;12(8):1963-8. doi: 10.1016/j.bmc.2004.01.010.

Authors

Khalid Mohammed Khan¹, Sajid Iqbal, Muhammad Arif Lodhi, Ghulam Murtaza Maharvi, Zia Ullah, Muhammad Iqbal Choudhary, Atta-Ur Rahman, Shahnaz Perveen

Affiliation

¹ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hassaan2@super.net.pk

PMID: 15051064
DOI: 10.1016/j.bmc.2004.01.010

Abstract

A variety of biscoumarins (1-21) with variable substituents at C-11 were synthesized with an improved method and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 15.06-91.35 microM. The size and electron donating or withdrawing effects of substituents influenced the activity, which lead to the urease inhibitors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Coumarins / chemical synthesis*
Coumarins / economics
Coumarins / pharmacology*
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / economics
Enzyme Inhibitors / pharmacology
Urease / antagonists & inhibitors*
Urease / metabolism

Substances

Coumarins
Enzyme Inhibitors
coumarin
Urease