The Australian Mohs database, part II: periocular basal cell carcinoma outcome at 5-year follow-up

Ophthalmology. 2004 Apr;111(4):631-6. doi: 10.1016/j.ophtha.2003.11.004.


Objective: To report the outcome with 5-year strict follow-up (only cases where 5-year follow-up is available) of all patients with periocular basal cell carcinoma (BCC) treated with Mohs' micrographic surgery (MMS) in Australia between 1993 and 1996.

Design: Prospective, noncomparative, multicenter, interventional case series.

Methods: A prospective series of 819 patients, undergoing MMS for periocular BCC over a 3-year period (1993-1996).

Inclusion criteria: Periocular BCC referred for MMS.

Main outcome measures: Recurrence, site, size, prior occurrence, defect size, histologic subtype, and presence of perineural invasion.

Results: Eight hundred nineteen patients had 257 (54%) lower eyelid, 195 (41%) medial canthus, and 22 (5%) upper eyelid BCCs. The most common histologic subtypes were nodulocystic (43%) and infiltrating (30%) (P = 0.0003). Sixty-eight percent were primary and 32% were recurrent tumors. Five-year follow-ups for cases between 1993 and 1996 were available in 347 (42%) cases. There were 7 recurrences (2.0%; exact 95% confidence interval [CI]: 0.82%-4.1%), 5 of which were at the medial canthus and all of which were previously recurrent, with up to 3 recurrences before MMS. Previous recurrence (P<0.0001), infiltrating (5) or superficial (2) histologic subtype (P = 0.0882), and medial canthal site were the main predictors of recurrence after MMS. There were no recurrences for primary BCC, and the 5-year recurrence for previously recurrent BCC was 7.8% (exact 95% CI: 3.2%-15.4%).

Conclusion: The Australian MMS database is the largest prospective nationwide series of periocular BCC managed by MMS. The strict 5-year recurrence rates of 0% and 7.8% for primary and recurrent tumors, respectively, confirm MMS as the treatment of choice for periocular BCC.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Australia
  • Carcinoma, Basal Cell / pathology
  • Carcinoma, Basal Cell / surgery*
  • Databases, Factual
  • Eyelid Neoplasms / pathology
  • Eyelid Neoplasms / surgery*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Mohs Surgery*
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local
  • Prospective Studies
  • Treatment Outcome