Nebulized salbutamol vs salbutamol and ipratropium combination in asthma

Indian J Pediatr. 2004 Feb;71(2):121-4. doi: 10.1007/BF02723090.


Objective: To see the additional benefit of combined frequent nebulization with salbutamol and ipratropium bromide in acute attack of asthma with moderate severity.

Methods: Fifty asthmatic children in the age range of 6-14 years were divided into two equal groups. Group I children were nebulized with three doses of Salbutamol alone (0.03 ml/kg/dose) and Group II children were given combined nebulization of Salbutamol (dose as in group I) and Ipratropium bromide (250 microgm/dose for three doses) at 20 minutes interval. Children were observed at 15, 30, 60, 120, 180 and 240 minutes interval.

Results: A significant improvement in % of PEFR starting at 30 minutes and lasting the entire study period of 4 hours was noted in both the groups. However on analysis of varience the results were better in group II.

Conclusion: Frequent combined nebulization with Salbutamol and Ipratropium bromide is beneficial in acute asthma of moderate severity.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Albuterol / therapeutic use*
  • Asthma / drug therapy*
  • Bronchodilator Agents / therapeutic use*
  • Child
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Humans
  • Ipratropium / therapeutic use*
  • Nebulizers and Vaporizers*
  • Prospective Studies
  • Treatment Outcome


  • Bronchodilator Agents
  • Ipratropium
  • Albuterol