Does whipworm increase the pathogenicity of Campylobacter jejuni? A clinical correlate of an experimental observation

Can J Gastroenterol. 2004 Mar;18(3):175-7. doi: 10.1155/2004/298064.


Campylobacter jejuni is a leading cause of acute diarrhea worldwide, usually mild and self-limiting. No adequate hypothesis has yet been formulated to explain why in an otherwise healthy host this infection is occasionally severe. In a pig model, C jejuni has been shown to be pathogenic only in the presence of swine whipworm. A human case of life-threatening C jejuni colitis leading to toxic megacolon and acute renal failure, associated with concomitant whipworm (Trichuris suis) ova in the feces, is reported. The potential of T suis to potentiate C jejuni in humans deserves further study.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / etiology*
  • Adult
  • Animals
  • Campylobacter Infections / complications*
  • Campylobacter jejuni* / pathogenicity
  • Humans
  • Male
  • Megacolon, Toxic / etiology*
  • Trichuriasis / complications*
  • Trichuris*