The role of human herpes virus 6 and 7 in the pathogenesis of pityriasis rosea

Int J Clin Pract. 2004 Feb;58(2):119-21. doi: 10.1111/j.1368-5031.2004.0003.x.


Pityriasis rosea (PR) is an acute exanthematous inflammatory skin disease in which many epidemiological studies suggest a viral infection in its pathogenesis. Several viruses such as picornaviruses, parvoviruses and herpes viruses were accused as causative agents in PR. Human herpes virus-6 (HHV-6) and HHV-7 are newly discovered members of herpesviridae family. Several diseases including roseola infantum and PR have been linked with HHV-6 and HHV-7 in dermatology. We aimed to investigate the role of HHV-6 and HHV-7 in the pathogenesis of PR. Blood samples from 35 patients with acute PR and 30 healthy volunteers were examined to obtain titres for HHV-6 and HHV-7 antibodies. Anti-HHV-6 and -HHV-7 immunoglobulin (Ig) G antibodies were detected by IFA. The high titres of anti-HHV-6 IgG were determined in four patients and anti-HHV-7 IgG in only two of four patients. In our study, we haven't found any significant relationship between HHV-6, HHV-7 and PR. Our results were supported with the data of several previous studies.

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Herpesvirus 6, Human*
  • Herpesvirus 7, Human*
  • Humans
  • Male
  • Pityriasis Rosea / drug therapy
  • Pityriasis Rosea / virology*
  • Roseolovirus Infections / complications*