From road rash to top allergen in a flash: bacitracin

Dermatol Surg. 2004 Apr;30(4 Pt 1):521-4. doi: 10.1111/j.1524-4725.2004.30168.x.

Abstract

Background: Bacitracin is an antibiotic that is produced by Bacillus subtilis, which is used in several types of consumer products, including cosmetics and ophthalmic and cutaneous ointments.

Objective: To call attention to the rising allergic contact dermatitis associated with bacitracin.

Results: Mass usage has resulted in an increasing number of clinically relevant allergic contact dermatitis reactions and near fatal anaphylaxis. The North American Contact Dermatitis Group has recorded its emergence as a leading allergen and continues to monitor the ever-growing allergic reaction rates.

Conclusion: The clinical impact, scientific evidence, and need for medical cost containment all advocate the discontinuation of routine usage of bacitracin in clean surgical wounds.

Publication types

  • Review

MeSH terms

  • Administration, Topical
  • Anti-Infective Agents, Local / administration & dosage
  • Anti-Infective Agents, Local / adverse effects*
  • Bacitracin / administration & dosage
  • Bacitracin / adverse effects*
  • Dermatitis, Allergic Contact / etiology*
  • Drug Eruptions / etiology*
  • Humans

Substances

  • Anti-Infective Agents, Local
  • Bacitracin