Vitamin E dietary supplementation inhibits transforming growth factor beta 1 gene expression in the rat liver

FEBS Lett. 1992 Aug 24;308(3):267-70. doi: 10.1016/0014-5793(92)81290-3.


Overexpression of transforming growth factor beta 1 (TGF beta 1) and increased transcription of pro-collagen type I, are known to represent major events implicated in the development of liver fibrosis under either experimental or clinical conditions. Here we report that long-term dietary vitamin E supplementation in animals undergoing an experimental model of liver fibrosis (induced by chronic treatment of rats with carbon tetrachloride) results in a net inhibition of both hepatic TGF beta 1 and alpha 2 (I) procollagen mRNA levels. Moreover, of striking interest is the observation that vitamin E supplementation per so down-modulates basal levels of TGF beta 1 mRNA in the liver of untreated animals, suggesting that a dietary regimen rich in vitamin E may potentially interfere with both the initiation and progression of the fibrosclerotic processes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diet
  • Gene Expression / drug effects
  • Liver / drug effects*
  • Liver / metabolism
  • Liver Cirrhosis, Experimental / metabolism
  • Liver Cirrhosis, Experimental / prevention & control
  • Male
  • Procollagen / biosynthesis
  • RNA, Messenger / genetics
  • Rats
  • Rats, Inbred Strains
  • Transcription, Genetic
  • Transforming Growth Factor beta / genetics
  • Vitamin E / administration & dosage
  • Vitamin E / pharmacology*


  • Procollagen
  • RNA, Messenger
  • Transforming Growth Factor beta
  • Vitamin E