Acute HIV revisited: new opportunities for treatment and prevention

J Clin Invest. 2004 Apr;113(7):937-45. doi: 10.1172/JCI21540.


Inability to recognize incident infection has traditionally limited both scientific and public health approaches to HIV disease. Recently, some laboratories have begun adding HIV nucleic acid amplification testing to HIV diagnostic testing algorithms so that acute (antibody-negative) HIV infections can be routinely detected within the first 1-3 weeks of exposure. In this review article, we will highlight critical opportunities for HIV treatment and prevention that are presented by these diagnostic strategies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acute Disease
  • HIV Infections / physiopathology
  • HIV Infections / prevention & control*
  • HIV Infections / therapy*
  • Humans