[Study on effect of flavonoids from oil-removed seeds of Hippophae rhamnoides on inducing apoptosis of human hepatoma cell]

Zhong Yao Cai. 2003 Dec;26(12):875-7.
[Article in Chinese]


Objective: To investigate the inhibitory and apoptosis-inducing effects of flavonoids from oil-removed seeds of Hippophae rhamnoides (FSH) on liver cancer cell line BEL-7402.

Methods: SRB, Wright staining, electron microscope and flow cytometry are used to study the effects of STT on BEL-7402 cell line.

Results: FSH has potent inhibitive effect on BEL-7402 cell line in a concentration-dependent manner. BEL-7402 cells exhibit typical morphological alteration of apoptosis when sub-Gl peak can be seen.

Conclusion: FSH exerts its inhibitive effect on BEL-7402 cells by inducing apoptosis.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / pharmacology
  • Apoptosis / drug effects*
  • Carcinoma, Hepatocellular / pathology*
  • Drugs, Chinese Herbal / pharmacology*
  • Flavonoids / pharmacology*
  • Hippophae* / chemistry
  • Humans
  • Liver Neoplasms / pathology*
  • Plants, Medicinal / chemistry
  • Seeds / chemistry
  • Tumor Cells, Cultured


  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Flavonoids