Objective: To investigate the inhibitory and apoptosis-inducing effects of flavonoids from oil-removed seeds of Hippophae rhamnoides (FSH) on liver cancer cell line BEL-7402.
Methods: SRB, Wright staining, electron microscope and flow cytometry are used to study the effects of STT on BEL-7402 cell line.
Results: FSH has potent inhibitive effect on BEL-7402 cell line in a concentration-dependent manner. BEL-7402 cells exhibit typical morphological alteration of apoptosis when sub-Gl peak can be seen.
Conclusion: FSH exerts its inhibitive effect on BEL-7402 cells by inducing apoptosis.