Churg-Strauss syndrome associated with the leukotriene antagonist montelukast

Neurol Sci. 2004 Apr;25(1):21-2. doi: 10.1007/s10072-004-0221-y.


Churg-Strauss syndrome (CSS) is a disseminated small vessel vasculitis characterized by late-onset asthma, upper airways disease, eosinophilia and late neurological manifestations such as peripheral neuropathy. Recently, several cases of CSS have been reported in patients treated with leukotriene antagonists after weaning corticosteroids. We describe a case of CSS developed while the patient was receiving montelukast for asthma treatment, after corticosteroids withdrawal. A causal relationship between montelukast therapy and CSS is hypothesized.

Publication types

  • Case Reports

MeSH terms

  • Acetates / adverse effects*
  • Aged
  • Asthma / drug therapy
  • Churg-Strauss Syndrome / chemically induced*
  • Churg-Strauss Syndrome / physiopathology
  • Cyclopropanes
  • Electrophysiology
  • Female
  • Humans
  • Leukotriene Antagonists / adverse effects*
  • Pain / chemically induced
  • Peripheral Nervous System Diseases / chemically induced
  • Quinolines / adverse effects*
  • Sulfides


  • Acetates
  • Cyclopropanes
  • Leukotriene Antagonists
  • Quinolines
  • Sulfides
  • montelukast